This Is How Sugar Disrupts Gut Bacteria And Leads To Obesity

— Azat Valeev /

We know that diabetes is basically caused by the dysfunction of insulin secretion in the body. This problem can have several origins. One of those origins is a disruption of gut bacteria, according to a new study.

It’s a fact: too much sugar and fat can be harmful to your health

The microbes, bacteria and many other microorganisms that inhabit our gut are essential to our health. While they play an indispensable role in digestion, numerous studies have shown that the gut microbiota influences the immune system, heart health, brain function and many other aspects of health. Since the gut microbiota is found in the intestinal tract, these organisms are affected by what we eat.

And a new study by Columbia University researchers has shown that dietary sugar alters the gut microbiome, setting off a chain of events that leads to metabolic disease. While it’s long been known that excessive sugar and fat consumption are associated with these diseases, this new study is no less important. In particular, it contributes to the search for ways to prevent or cure this type of disease.

According to the results of the study published in the journal Celldiets high in sugar and fat – especially the Western-style diet – increase the risk of diabetesmetabolic disorder andobesity. To reach this conclusion, the researchers subjected mice to this diet for four weeks. After this time, the mice were found to gain weight and show signs of insulin resistance and metabolic disease.

— kurhan /

New perspectives in the prevention and treatment of metabolic problems

By performing further analyses, the researchers also found that the composition of the mice’s gut microbiome changed significantly. Specifically, levels of segmented filamentous bacteria dropped, while levels of other microbes rose. Note that these filamentous bacteria are linked to immune cells called TH17 lymphocytes, and the decrease in these bacteria has led to a decrease in these lymphocytes. However, TH17 lymphocytes seem to play a very important role in the prevention of metabolic diseases and weight gain.

These immune cells produce molecules that slow the absorption of bad lipids by the intestines and decrease intestinal inflammation. In other words, they keep the intestine healthy and protect the body against the absorption of pathogenic lipids. “, explained in particular Ivalyo Ivanov, lead author of the study, in a statement. Given these results, the researchers hope that further studies will be carried out to develop therapeutic plans that target TH17 for the prevention of metabolic diseases.

Furthermore, the researchers also found that while sugar and fat do influence the level of TH17 in the body, reducing sugar consumption does not necessarily restore the balance. In other words, in some people, dietary interventions that involve reducing sugar intake may not be effective. In these cases, probiotic-based treatments may be more effective.

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